Molecular biology of podocyte

Update in podocyte biology.

Knowledge of podocyte biology is growing rapidly. Podocytes are crucially involved in most hereditary diseases affecting the glomerulus, which all exhibit podocyte-specific defects, that is, foot process effacement and protein leakage. Efforts to understand molecular mechanisms causing these derangements are increasingly successful and will allow a better targeting of interventions to halt the ...

Cell biology of the glomerular podocyte.

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their most prominent features are interdigitated foot processes with filtration slits in between. These are bridged by the slit diaphragm, which plays a major role in establishing the selective permeability of the glomerular filtration barrier. Injury to podocytes leads to proteinuria, a hallmark of most glomerul...

Podocyte Biology in Glomerular Health and Disease

s Nephron 2016;132:245–291 DOI: 10.1159/000445271 257 ing childhood NS. Moreover, reductions in glomerular and podocyte SULF2 expression also corresponded with injury, while glucocorticoid treatment restored SULF2 in podocytes. Our data suggest that SULF2 plays an important role in glucocorticoid response in NS.

Systems biology versus molecular biology

Systems biology and molecular biology can answer the same question in quite different ways, and frequently the answers given by one sub-discipline seem no answer at all to the other. For many molecular biologists, a systemslevel explanation leaves them feeling that, until the underlying molecular mechanisms are known, the approach is hopelessly superficial. For systems biologists, on the other ...

The 15th Iranian National Congress of Biochemistry & 6th International Congress of Biochemistry and Molecular Biology